SAYRE, David Austen, philanthropist, born in Bottle Hill, New Jersey, 12 March, 1798" died in Lexington, Kentucky, 11 September, 1870. He removed in early life to Lexington, where he became a successful merchant and banker. Though repeatedly meeting with heavy losses, he gave about $500,000 to benevolent objects during his life-time, including $100,000 to found the Sayer institute.-His nephew, Lewis Albert, surgeon, born in Bottle Hill (now Madison), New Jersey, 29 February, 1820, was graduated at Transylvania university, Kentucky, in 1838, and at the College of physicians and surgeons in 1849. The office of prosector to Dr. Willard Parker, professor of surgery in that institution, was at once given to him, and he held it until 1852. He was appointed in 1853 surgeon to Bellevue hospital, and in 1859 surgeon to the Charity hospital on Blackwell's island, both of which posts he continued to hold until 1873, when he became consulting surgeon. Dr. Sayre advocated clinical practice in medical colleges, and was in 1861 among the first to suggest the establishment of Bellevue hospital medical college. On the formation of its faculty, he became professor of orthopedic surgery, and fractures and luxations, and later of clinical surgery, which chair he still (1888) holds. In 1844 he was appointed hospital surgeon of the 1st division of the New York state militia, but he resigned in 1866. Since 1870 he has been consulting surgeon to the Home for incurables in Westchester county, New York From 1860 till 1866 he was resident physician of the city of New York, during which time he presented many papers to the board of health. Among these was one showing that cholera is a portable disease, if not a contagious one, and could be prevented by efficient quarantine regulations. In 1876 he was appointed by the American medical association a delegate to the International medical congress that convened in Philadelphia, and in 1877 he was sent by the same body as a delegate to the British medical association. On this occasion he was invited to give demonstrations of his mode of treatment of hip-joint and spinal diseases in the University college hospital, Guy's, St. Bartholomew's, St. Thomas's, and the Royal orthopedic hospital in London, also in Liverpool, Manchester, Birmingham, and Cork. In 1879 he went as a delegate to the 6th International medical congress in Amsterdam, and before that body gave demonstrations of his plan of treatment for Port's disease and lateral curvature of the spine. He was present at the International medical congresses in London in 1881, Copenhagen in 1884, and in Washington in 1887, at each of which he read papers descriptive of his recent improvements in the treatment of the diseases of which he makes a specialty. Dr. Sayre's inventions include many surgical appliances, among which are a uvulatome, splints for extension of the hip-, knee-, and ankle-joints in chronic disease, a flexible probe, improved tracheotomy-tube, bristle probang for removing foreign bodies from the oesophagus, scrotal clamp, club-foot shoe, new method for treating fractured clavicle, and the use of plaster of Paris in the treatment of spinal diseases and curvature. In 1872 he was made a knight of the order of Wasa by Charles XIV., king of Sweden and Norway, for his services to medical science, lie is a member of numerous medical societies at home and abroad, and was one of the original members of the American medical association, of which he was vice-president in 1866, and president in 1886. His bibliography is exceedingly large, consisting chiefly of contributions to professional journals, and includes the books "Practical Manual of the Treatment of Club-Foot" (New York, 1869)" "Lectures on Orthopedic Surgery and Diseases of the Joints" (1876), of which several editions have been issued and which have been re-published in Germany and France" and "Spinal Curvature and its Treatment" (London, 1877).