OTT, Isaac, physician, born in Northampton county, Pennsylvania, 30 November, 1847. He studied in Lafayette college, was graduated at the medical department of the University of Pennsylvania in 1869, and studied medicine in Germany and London. In 1878 he organized a physiological laboratory in the University of Pennsylvania, and lectured for a year on experimental physiology. He was made a fellow in biology at Johns Hopkins in 1878. Dr. Ott has devoted considerable study to the physiological action of drugs, and discovered the path and decussation of the sudorific, sphincter-inhibitory, and thermo-inhibitory fibres in the spinal cord, the innervation of sphincters, and the location of the fever-centres in the brain. He has published " Cocaine, Veratria. and Gelseminum" (Philadelphia, 1874) ; "Action of Medicines" (1878); and" Contributions to Physiology and Pathology of the Nervous System" (Easton, 1879-'87).